Widely published in both local and international journals and books of various topics related to cardiovascular medicine. Internationally recognized for her outstanding work in the area of heart failure. Collaborations with a range of prestigious national and international clinical and academic centers. She holds an appointment as adjunct professor at the University of Queensland, Brisbane, Australia and as a visiting professor at the Baker Institute in Melbourne, Australia.
The Brain and Behaviour Initiative BBI enables cross-faculty, multidisciplinary, collaborative research in the cognitive and affective neurosciences and brings together expertise on phenotyping, genotyping, cognotyping, brain imaging and molecular signatures to address brain-behaviour issues. New experimental techniques including brain imaging, genetic testing and neuropsychological assessment combined with new theoretical insights have opened up significant potential for the advancement of novel diagnostic tools and treatments for people with mental disorders.
The initial focus on trauma and resilience has now extended to work in substance use and NeuroHIV. Her research focuses on child lung health including HIV-associated lung disease, childhood pneumonia and childhood TB. In she received the World Lung Health Award, awarded by the American Thoracic Society at a ceremony in San Diego, in recognition of work that has "the potential to eliminate gender, racial, ethnic, or economic health disparities worldwide".
Currently regarded as a thought leader in Rheumatic Heart Disease, both on the continent and internationally. Has significant international research collaborations within the Rheumatic Heart Disease Community and within the Cardiovascular Community. Her social responsibility is reflected in, amongst others, numerous board positions; and she continues to be involved in teaching, training and mentorship encompassing courses directed at nurse practitioners, clinical officers and echocardiography masterclasses in South Africa, Ethiopia, Zambia and Uganda.
Skip to main content. Affiliate Members. Share on. The research goal is to improve understanding of the immunopathology of TB and HIV, using this information to aid in developing novel therapeutic approaches and diagnostic biomarkers. His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M.
His work has a strong translational component, asking if both classically and non-classically restricted T cells are associated with infection with M. The translational significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB.
Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus. Recent studies published in PloS Pathogens, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design.
Research interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world. More specifically, the reconstitution of the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TB , and pathogenesis such as the Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.
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